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Image Search Results
Journal: bioRxiv
Article Title: Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen
doi: 10.1101/2020.12.22.423938
Figure Lengend Snippet: (A) Liver injury progression after IFNα treatment. The graph shows sALT levels in WT mice (white bars) and HBs-Tg mice (black bars) after IFNα treatment (5MU/kg). Mean values +/− s.d of pooled data from 3 independent experiments are shown. (B) Differentially expressed genes (DEGs) in the microarray data of HBs-Tg and WT mice after IFNα treatment. Each of the 6 graphs shows a distinct cluster identified using microarray time-course-specific maSigPro software. (C) List of gene pathways selectively enriched in the 6 clusters. (D) A schematic diagram showing simplified unfolded response pathways. (E) Representative immunoblots showing UPR-biomarker protein expression in HBs-Tg mice (left panel) and WT mice (right panel) at specified time points after IFNα treatment.
Article Snippet: Purified labeled-cRNA and controls (Agilent One Color Spike-In Kit) were hybridized to
Techniques: Microarray, Software, Western Blot, Biomarker Assay, Expressing